Die Deutsche Forschungsgemeinschaft (DFG) wird ab Anfang 2007 16 neue

Schwerpunktprogramme fördern.


Zum Programm SPP 1267 "Sphingolipide - Signale und Krankheit" wurde nun die

Ausschreibung veröffentlicht. Sie finden den AUsschreibungstext (in englischer

Sprache) am Ende dieser Nachricht.


Deadline für Proposals: 18. September 2006


Wissenschaftliche Nachfragen:

Prof. Dr. Erich Gulbins,

Institut für Molekularbiologie, Universität Duisburg-Essen, Hufelandstrasse 55

45122 Essen

tel: 0201-723-3118, fax: 0201-723-5974,

e-mail: erich.gulbins(at)uni-essen.de.


Administrative Nachfragen:

Dr. Stefan Lohwasser,

tel: 0228-885-2359, fax: 0228-885-2777,

e-mail: stefan.lohwasser(at)dfg.de


Sabine Pichler,

tel: 0228-885-2752,

e-mail: sabine.pichler(at)dfg.de




Ausschreibungstext, DFG, 19. Mai 2006:


The Senate of the Deutsche Forschungsgemeinschaft (DFG, German Research

Foundation) has established the Priority Programme “Sphingolipids – Signal and

Disease“. The programme is designed to run for six years.


The aim of this programme is to study the physiology, biochemistry, pathology,

pharmacology, medical chemistry and the medical application of bioactive

sphingolipids and their derivatives. Sphingolipids are central to the spatial

and temporal organisation of cellular signalling molecules and are critically

involved in the regulation of cell death, proliferation, cellular

differentiation and the pathogenesis of many diseases. Hence, the programme

particularly intends to characterise the novel signalling mechanisms and the

receptor crosstalks that mediate cellular effects of ceramide,

ceramide-1-phosphate, sphingosine and sphingosine 1-phosphate, as well as their

derivatives. It will also serve to identify and analyse receptors and

signalling mechanisms involved in this mediation process. As far as the role of

sphingolipids in human diseases is concerned, it would be highly beneficial to

develop new lead compounds and drugs that manipulate these lipids and serve to

treat cardio-reno-vascular, neurodegenerative, neuro-psychiatric, inflammatory,

tumour and immunological disorders.


The present call is limited to proposals that translate basic scientific

knowledge about cellular regulation and functions of sphingolipids into novel

therapeutic strategies and regimens. However, all proposals should focus on the

study of the regulation and function of these lipids and their derivatives.

They should be hypothesis driven and provide proof of concepts and principles

at least as preliminary data. Exploratory and exclusively descriptive studies

will only be funded if they are combined with studies on the principle biology

or the biomedical application of sphingolipids. Collaboration with other

research groups and the creation of synergies are encouraged. Studies on other

phospholipids or eicosanoids or research on predominantly descriptive genomes

and proteomes are excluded from this call.


Selection will be based on the quality of the proposal and the preliminary

data. Applications by junior scientists are encouraged. Applicants must have a

solid, high-quality publication record on sphingolipid research and, depending

on the seniority of the principle investigator, an established record of

extramural funding.


Proposals for an initial three-year funding period should be submitted on paper

in triplicate, including appendices (one original, two copies), and on CD-ROM.

The CD-ROM should include the proposal and all appendices (publications,

etc.), preferably as PDF (or RTF) files. Proposals must be written in English,

and the title and project summary should also be provided in German. Please

submit proposals, marked as “SPP 1267” and addressed to the attention of Dr.

Stefan Lohwasser, to the Deutsche Forschungsgemeinschaft, Kennedyallee 40,

53175 Bonn. The deadline for submission is 18 September 2006. For scientific

enquiries please contact the programme coordinator, Prof. Dr. Erich Gulbins,

Institut für Molekularbiologie, Universität Duisburg-Essen, Hufelandstrasse 55,

45122 Essen, tel: 0201-723-3118, fax: 0201-723-5974, e-mail:

erich.gulbins(at)uni-essen.de. For administrative enquiries please contact Dr.

Stefan Lohwasser, tel: 0228-885-2359, fax: 0228-885-2777, e-mail:

stefan.lohwasser(at)dfg.de, or Sabine Pichler, ph: 0228-885-2752, e-mail: